When the body of a former Ambassador's daughter is found brutally murdered in her uptown home, Detectives Goren and Eames question a jealous ex-boyfriend. But when another body shows up with a similar crime scene, Detective Goren's old mentor and his daughter suddenly return to warn of a past serial killer back on the loose. The search gets personal as a member of the Major Case Squad is kidnapped.

Keith Cooper is no stranger to his dad's womanizing ways, but when Dr. Grant Cooper winds up dead after his motorcycle is found sabotaged, Detectives Logan and Wheeler find a private collection of the Doctor's personal conquests. When Keith's high-school teacher, Danielle shows up on one of tapes, the Detectives assume her jealous husband is to blame. But the case takes a major turn when the Detectives find Danielle in the arms of her under-aged student.

A supermodel who crosses paths with Goren and Eames during their investigation into the murder of a teen with a party-girl reputation.

Logan and Wheeler investigate a firefighter's stabbing death, a crime that took place after the victim prevented a hate crime.

Goren and Eames must sort through complicated family dynamics when the favorite son of a patronizing father's two grown children is found poisoned to death. The long list of suspects is reduced by one as the detectives stumble upon another murder.

Goren and Eames revisit the 1992 murder of a little girl after a sex offender confesses to the crime. Liza Minnelli guest stars as the victim's mother, a former beauty queen who had been suspected of killing her daughter.

Logan and Wheeler must sort through multiple motives as they investigate an award-winning music producer's death.

Detectives Goren (Vincent D'Onofrio) and Eames (Kathryn Erbe) are called in from time with their families to help Commissioner Leland Dockerty (guest star Michael Biehn) and his wife, Elaine (guest star Fran Drescher) find their daughter, a female soldier, who goes missing while home on leave. Goren struggles to remain professional and attentive to the case while his ailing mother (guest star Rita Moreno) takes a turn for the worse. Eric Bogosian also stars.

The investigation into the beating death of a former child star takes an intriguing turn when Logan and Wheeler discover that the victim had ties to the Albanian mob.

The kidnapping of a popular video blogger and her boyfriend---which is witnessed live on the Internet---seems suspicious to Logan and Wheeler.

The death of a young, pregnant Pakistani woman leads Logan and Wheeler to question the man she was secretly dating, as well as both his and the victim's disapproving relatives.

Goren and Eames uncover a deadly web of secrets when they investigate the murder of a prominent socialite's granddaughter.

A judge ends up a real-life casualty when he takes part in a reenactment of a famous historic duel. Goren and Eames question the victim's opponent, whose wife is running for mayor of New York City.

A rap artist is shot after a radio interview, and the only witness is an undercover cop whose task force specializes in rap-world crimes.

A prominent televangelists wife is murdered following a rally and Goren and Eames are put on the case. However, Goren's head is not in the case while he copes with his mother's deteriorating medical condition and the reappearance of his long-lost brother.

Logan and Wheeler are put on the case when Josh Lemle, a reporter friend of Logan's, comes to Major Case to report his own murder by poisoning. Logan agrees to help find out who used Polonium-210 to poison him, but Lemle is less than cooperative when he refuses to tell Logan the entire story. The case escalates, and both the Haz-mat team and the FBI join the case in order to get Homeland Security the answers they are demanding.

Logan and Wheeler are sent to the scene when a judge's son is brutally murdered following the sentencing of a rapper by the judge. However, after further investigation, detectives find that the boy's death may be more related to his friends than the sentencing of the rapper.

Goren and Eames look into the murder of a doctor who whad been involved in a case concerning the deaf and controversial implants. The detectives soon find themselves working with a detective who knows how to sign and work together to find the doctor's elusive murderer.

A female astronaut is found murdered in her hotel room on the morning of a press conference. The investigation leads to several suspects, including a jealous professional rival, an ex-boyfriend and a married space-shuttle commander with whom the victim was having an affair.

The death of a stripper-turned-celebrity's son appears to be an accidental overdose, but when the woman dies days later after giving birth, the case becomes a homicide investigation that seems to involve the paternity of the newborn.

A death-row inmate hoping to stall his execution produces scrapbooks filled with information on several unsolved cases. But more disturbing for Goren is a picture of his mother found in one of the collections.

As the sixth season ends, a hero police recruit is found murdered soon after he breaks up a robbery. While working the case, Logan starts a relationship with a woman from his building; and Wheeler is asked to oversee a past case, so Detective Eames steps in.